Pyrrolidine CAS 123-75-1

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Pyrrolidine CAS 123-75-1

Pyrrolidine CAS 123-75-1 tetrahydropyrrole, hot selling in Europe/Russia/Ukraine.

CAS 123-75-1 Basic Parameter

Product Name Pyrrolidine
CAS NO 123-75-1
Molecular Formula C4H9N
Molecular Weight 71.12
Melting point -63 °C
Boiling Point 87-88 °C(lit.)
Flash Point 37 °F
Density 0.866
Assay ≥99%
Grade Pharmaceutical Grade
Solubility Miscible with alcohol, ether, chloroform and water.
Appearance It is a colorless or yellow liquid with a special smell

Tetrahydropyrrole Picture

pyrrolidine, tetrahydropyrrole, cas 123-75-1, tetramethyleneimine, C4H9N

What is Pyrrolidine?

Pyrrolidine, also known as tetrahydropyrrole, is an organic compound with the molecular formula (CH2)4NH. It is a cyclic secondary amine, also classified as a saturated heterocycle. It is a colourless liquid that is miscible with water and most organic solvents. It has a characteristic odor that has been described as “ammoniacal, fishy, shellfish-like”. In addition to pyrrolidine itself, many substituted pyrrolidines are known.

Production and synthesis

Industrial production

CAS 123-75-1 is prepared industrially by the reaction of 1,4-butanediol and ammonia at a temperature of 165–200 °C and a pressure of 17–21 MPa in the presence of a cobalt- and nickel oxide catalyst, which is supported on alumina.

Reaction of 1,4-butanediol with ammonia to form pyrrolidine and water in the presence of a nickel oxide catalyst supported on alumina

The reaction is carried out in the liquid phase in a continuous tube- or tube bundle reactor, which is operated in the cycle gas method. The catalyst is arranged as a fixed-bed and the conversion is carried out in the downflow mode. The product is obtained after multistage purification and separation by extractive and azeotropic distillation.

Laboratory synthesis

In the laboratory, pyrrolidine was usually synthesised by treating 4-chlorobutan-1-amine with a strong base:

Synthesis of pyrrolidine

Furthermore, 5-membered N-heterocyclic ring of the pyrrolidine derivatives can be synthesized via cascade reactions.


Pyrrolidine is a base. Its basicity is typical of other dialkyl amines. Relative to many secondary amines, pyrrolidine is distinctive because of its compactness, a consequence of its cyclic structure.

Pyrrolidine is used as a building block in the synthesis of more complex organic compounds. It is used to activate ketones and aldehydes toward nucleophilic addition by formation of enamines (e.g. used in the Stork enamine alkylation):


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