Dimethocaine CAS 94-15-5 Larocaine

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Dimethocaine CAS 94-15-5 Larocaine DMC

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Larocaine Basic Parameter

Product Name: Dimethocaine / Larocaine
Synonyms: Larocaine;NSC 68927;Brn 2215967;DiMethocine;Dimethocaine;Larocaine;Dimethocaine>Larocaine 94-15-5;Dimethocaine/Larocaine;dimethocaine
CAS NO: 94-15-5
Molecular Formula: C16H26N2O2
Molecular Weight: 278.39
Density 1.0±0.1 g/cm3
Melting Point: N/A
Boiling point: 403.5±25.0 °C at 760 mmHg
Flash Point 197.8±23.2 °C
Appearance: white powder

CAS 94-15-5 Picture

Dimethocaine, CAS 94-15-5, Larocaine, dmc

Dimethocaine, also known as DMC or larocaine, is a compound with a stimulatory effect. This effect resembles that of cocaine, although dimethocaine appears to be less potent. Just like cocaine, dimethocaine is addictive due to its stimulation of the reward pathway in the brain. However, dimethocaine is a legal cocaine replacement in some countries and is even listed by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) under the category “synthetic cocaine derivatives”. The structure of dimethocaine, being a 4-aminobenzoic acid ester, resembles that of procaine. It is found as a white powder at room temperature.


Dimethocaine and structurally related local anesthetics such as cocaine and procaine inhibit the uptake of dopamine (DA) by blocking dopamine transporters (DAT). The dopamine transporter controls the dynamics of the neurotransmitter dopamine. This neurotransmitter controls many functions including movement, cognition and mood. Drugs such as cocaine and dimethocaine induce dopamine overflow by inhibiting dopamine transporters and thus creating a euphoric effect. In addition to inhibiting dopamine uptake, dimethocaine was also shown to inhibit the binding of CFT, a different dopamine uptake inhibitor. These inhibitory properties are responsible for the stimulatory effects of dimethocaine on the central nervous system Both in vivo and in vitro measurements of dopamine transporter activity showed that dimethocaine is a potent and efficacious dopaminergic reuptake inhibitor (also called a dopamine indirect agonist). These effects were mainly observed in the nucleus accumbens, a region in the basal forebrain. Comparison of the pharmacological potencies of different local anesthetics revealed the following potency order:

cocaine > dimethocaine > tetracaine > procaine > chloroprocaine

Furthermore, the administration of dimethocaine has been shown to lead to antinociceptive responses at nontoxic doses in mice. These responses are suggested to be at least partially caused by the effects of dimethocaine on the central nervous system. A memory impairing effect observed in mice after administration of dimethocaine has been proposed to be a result of a non-anesthetic mechanism of action.


When inhaled, dimethocaine starts working in 10–30 minutes, with highest effects at 60–120 minutes and until 4–6 hours there is a period of action with the ‘after-effects’. The after effects include fatigue and slight mental impairment. 

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